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ORIGINAL ARTICLE
Year : 2021  |  Volume : 70  |  Issue : 3  |  Page : 136-139

Proliferative capacity of retinal progenitor cells in human fetal retina


1 Department of Anatomy, MGM Medical College, Navi Mumbai, Maharashtra, India
2 Department of Anatomy, MGM Medical College and Hospital, Navi Mumbai, Maharashtra, India

Correspondence Address:
Dr. Anjali Satyen Sabnis
Department of Anatomy, MGM Medical College and Hospital, Kamothe, Navi Mumbai . 410 209, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jasi.jasi_100_21

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Introduction: Retina is an innermost, delicate, and photosensitive layer of the eyeball, which is composed of 10 layers and 8 specialized cells which are involved in paramount function of the body like vision. Retinal neurogenesis commences from the layers of optic cup, which forms from optic vesicle. Progenitor cells are the tissue-specific cells which give rise to all different types of retinal cells. Progenitor cells in fetal retina proliferate at specific time during development of retina. Knowledge of the highest proliferative capacity interval of progenitor cells will be valuable for transplantation. Material and Methods: Twenty-eight fetuses of spontaneous abortions of 13th–40th week were collected from MGM Hospital after ethical and scientific approval of the institute. After fixation of fetuses, eyeballs were extracted and fixed in buffer solution. Sections were taken and the retina was treated with Ki-67 immunohistochemistry marker to observe proliferative capacity of retinal progenitor cells (RPCs). Seven groups (A to G) of 4 weeks were made and observations of each group were noted. Results: It was observed that the highest proliferative capacity of RPCs was in B group (17–20 weeks) and the highest proliferative capacity of RPCs was maximum at 19th week of gestation. Discussion and Conclusion: Characteristics of progenitor cells in retina are well studied. Their highest proliferation period can be utilized to make the procedure of transplantation more refined.


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